Preheat your oven to 350 degrees F. Prepare three 8-inch or four 6-inch round cake pans by spraying each pan with non-stick spray, covering the bottom of each pan with parchment paper and spraying the parchment paper with non-stick spray as well. Set aside.
In a medium bowl, combine the cake flour, baking powder and salt. Set aside.
In the bowl of a stand mixer fitted with the paddle attachment, combine the butter and sugar. Mix on medium speed until light and fluffy, about 2 minutes.
With the mixer on medium speed, add the egg whites and whole egg one at a time, mixing for about 30 seconds and scraping down the sides of the bowl between each addition. Add the butterscotch flavor and then turn the mixer to medium-high and beat for another 3 to 5 minutes until the batter has lightened in color and is fluffy in texture.
Turn the mixer to low speed and gradually add the dry ingredients and buttermilk alternately, starting and ending with the dry ingredients. Mix until incorporated, only about 20 seconds. Scrape down the sides of the bowl and mix on low for another 10 to 20 seconds.
Divide batter evenly between the pans, about 16 oz. of batter in each 8-inch pan or 12 oz in each 6-inch pan. Bake for 20 to 22 minutes, or until a toothpick inserted into the center of the cake comes out with a few moist crumbs on it.
Let the cakes cool in the pans for 10 minutes and then invert onto wire racks to cool completely.
Level each cake layer before assembly. If you're not using the layers right away, wrap each cake layer with plastic wrap and freeze.